Observational scientific tests have shown that concomitant utilization of opioid analgesics and benzodiazepines raises the possibility of drug-similar mortality compared to usage of opioid analgesics on your own.
Misuse of those medication can lead to addiction, poisoning, overdose, or even Demise. When you are prescribed these prescription drugs, it’s crucial that you simply speak to your health care provider about how to work with these medicines safely and securely.
If the decision is designed to prescribe a benzodiazepine or other CNS depressant concomitantly using an opioid analgesic, prescribe the bottom efficient dosages and minimum amount durations of concomitant use. In patients currently acquiring an opioid analgesic, prescribe a lower initial dose on the benzodiazepine or other CNS depressant than indicated within the absence of the opioid, and titrate determined by scientific reaction.
Steer clear of consuming grapefruit or drinking grapefruit juice when using this medication Unless of course your physician or pharmacist says you could do this safely and securely. Grapefruit can raise the probability of side effects using this medication. Talk to your medical professional or pharmacist For additional specifics.
Reserve concomitant prescribing of OXYCONTIN and benzodiazepines or other CNS depressants for use in individuals for whom alternative cure options are insufficient.
Also, final results from just one study have proven a link amongst particular start defects and using opioids by pregnant Females.
This get more info product or service could contain inactive substances, which often can trigger allergic reactions or other difficulties. Speak to your pharmacist for more details.
Oxycodone is an opioid medication utilised to treat moderate to critical ache when other soreness treatment options do not get the job done very well more than enough. Oxycodone helps lessen pain by activating opioid receptors inside the anxious program, as it can be an opioid agonist.
Situations of adrenal insufficiency happen to be described with opioid use, much more frequently subsequent higher than just one thirty day period of use.
Because of the opportunity for severe adverse reactions, such as extra sedation and respiratory despair within a breastfed toddler, recommend clients that breastfeeding just isn't proposed for the duration of treatment with OXYCONTIN.
If concomitant use is warranted, often Consider the affected person, significantly for the duration of therapy initiation and dose adjustment. Discontinue OXYCONTIN if serotonin syndrome is suspected.
Accidental ingestion of even one particular dose, specifically in children, can lead to a fatal overdose of oxycodone.
The concomitant use of OXYCONTIN with all cytochrome P450 3A4 inhibitors may possibly end in more info an increase in oxycodone plasma concentrations, which could enhance or prolong adverse drug effects and could result in probably fatal respiratory depression.
Opioids are sought for nonmedical use and therefore are subject matter to diversion from legitimate prescribed use. Take into consideration these challenges when prescribing or dispensing OXYCONTIN. Approaches to lower these threats involve prescribing the drug from the smallest correct amount and advising the patient on mindful storage of your drug through the training course of treatment and the appropriate more info disposal of unused drug.